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Anti Fungals

Anti Fungals

 

Infections caused by dermatophytes- fungi that invade only dead tissues of the skin or its appendages(stratum corneum, nails, hair). Tricophyton, Epidermophyton and microsporum are most commonly involved, but clinical differentiation of dermatophytes is difficult. Transmission is usually from person to person or animal to person.

Most skin infections respond very well to topical antifungal preparations, such as imidazols (ketoconozole). Resistant cases or those with widespread involvement require systemic therapy. All these formulations should strictly be taken on the advice of a registered medical practitioner. Rowan is having IYCOTIC(Ketoconazole) which is available in both oral and topical forms.& IYCOTIZOL( Itraconazole).

ANTI FUNGALS

 

ANTI FUNGALS

Specifications of IYCOTIC

Product Name
IYCOTIC Tablets
IYCOTIC Cream
IYCOTIC Shampoo

Ingredients & Pack
Each uncoated tablet contains Ketoconazole IP200mg. Alu-alu of 10’s, box of 10x10’s
Cream- Ketoconazole 2% w/w lami tube of 20gms and 50gms
Lotion- Ketoconazole 2% w/v per bottle of 100 ml.

Special Featurese
Iycotic is first orally available azole antifungal for the treatment of superficial and systemic fungal infections.
Iycotic impairs the synthesis of ergosterol, which is a vital component of fungal cell membranes.
It has activity against a no.of candida spp.,dermatophytes, malassezia furfur and some dimorphic fungi such as Blastomyces dermatitidis and coccidioides.
Iycotic successfully treats tinea capitis and p.versicolor.

Technical Specification
Ketoconazole is a synthetic broad spectrum Anti-Fungal which is white to slightly beige, odorless powder, soluble in acids, with molecular wt.of 531.44
Mean peak plasma levels of approx.3.5mcg./ml are reached in 1-2 hours of oral administration.
In Vitro Plasma Protein Binding is 99%.
About 13% of dose is excreted in urine, the major route of excretion is through the bile into intestinal tract.

Applications
Apply Iycotic cream twice daily or as advised by consultant. Apply Iycotic shampoo ten minutes before taking bath or as advised.

IYCOTIZOL

Specifications of IYCOTIZOL

Product Name
IYCOTIZOL 100mg and 200mg caps.

Ingredients & Pack
Each hard gelatine capsule contains itraconazole pallets 100mg and 200mg . Strip of 4’s box of 7x4’s

Special Features
IYCOTIZOL is broad spectrum triazole antifungal.
It is 99% Plasma protein bound, extensively metabolised.
Its active metabolite hydroxyitraconazole is antifungal too.
Covers dermatophytes,candida,malassezia and systemic fungal infections such as histoplasma, aspergillus etc...

Dosage
Tinea corporis tinea cruris 200 mg daily for one week OR 100mg daily for 2 weeks
Tinea pedis tinea manuum: 200 mg twice daily for one week OR 100mg daily for 2-4 weeks
Vulvovaginal candidiasis: 200 mg twice daily for one day OR 200 mg daily for 3 days
Oral candidiasis: 100 mg daily for two weeks
Tinea unguium: 200 mg/day for 6-8 weeks (fingernails) or 3-4 months (toenails), OR 200 mg twice daily for 7 days, repeated monthly for 2 months (fingernails) or 3-4 months (toenails)
Pityriasis versicolor: 200 mg/day for 10 days, with a preventative dose of 200mg once monthly for 6 months.
The dose in children is usually 5 mg per kg body weight per day to maximum 200 mg per day but is reserved for exceptional circumstances

Special Precautions
IYCOTIZOL capsules should not be given to the patients who have history of CHF or with any proof of ventricular dysfunction.
If signs or symptoms of congestive heart failure occur during therapy with Iycotizol caps., discontinue administration.

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